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Optical tweezers have a limited manipulation area (although this limitation has been challenged recently), and require high optical power that may lead to cell damage (for example, Koenig et al 1995a). Chiou et al (2005) discuss an interesting alternative: an optically patterned dielectrophoretic manipulator that requires 100,000 times less optical power than optical tweezers, manipulates >10,000 particles at a time, and permits an on-the-fly configuration of the manipulation scope and pattern by using a simple and inexpensive substrate. This latter feature opens a possibility for producing inexpensive and disposable particle manipulators. Chiou et al show that the manipulator can be used to sort particles based on their dielectic properties, for example, separate live from dead cells.
Ohta et al 2007 discuss a version of a dielectrophoretic manipulator which uses an optically controllable transparent fixed-electrode pattern to manipulate particles in suspension. The electrode pattern is deposited on a single substrate as opposed to the optically patterned dielectrophotoretic manipulator described by Chiou et al (2005). This is believed to simplify the manufacturing and integration of the fixed-electrode pattern manipulators.
| CITATION: Jonasz M. 2006. Optical-dielectrophoretic particle manipulation (www.tpdsci.com/Tpc/PtTpmODpho.php). In: Top. Part. Disp. Sci. (www.tpdsci.com). |
HISTORY: Published: 13-Jan-2006 Modified: 25-May-2007 Reviewed: PENDING |
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